Understanding how the small intestine grows and repairs its finger-like projections.
A molecular and physical mechanism for growing and branching the intestinal villus
This study is looking at how the small intestine grows and heals its tiny finger-like structures that help absorb nutrients, with the hope of finding better treatments for people with digestive issues like celiac disease and inflammatory bowel disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-11051051 on NIH RePORTER |
What this research studies
This research investigates the mechanisms that allow the small intestine to grow and repair its villi, which are essential for nutrient absorption. By studying the cellular processes and physical forces involved in villus formation, the research aims to uncover new therapeutic strategies for patients suffering from conditions like celiac disease and inflammatory bowel disease. The approach includes examining the role of specific cell types and signaling pathways that contribute to villus development and regeneration. Patients may benefit from insights that could lead to improved treatments for digestive disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research include adults with conditions that cause villus atrophy, such as celiac disease or those experiencing complications from chemotherapy.
Not a fit: Patients with intact intestinal villi or those without gastrointestinal disorders may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that enhance intestinal health and improve nutrient absorption for patients with gastrointestinal diseases.
How similar studies have performed: Other research has shown promising results in understanding intestinal regeneration, but this specific approach to villus growth is relatively novel.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Gartner, Zev Jordan — University of California, San Francisco
- Study coordinator: Gartner, Zev Jordan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.