Understanding how the shape of the eye lens changes with age
Biomechanics of Lens Morphogenesis
This study looks at how the eye lens changes as we get older and how those changes can lead to vision problems like presbyopia and cataracts, using a fun comparison to a balloon filled with jelly to help explain what happens over time.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project ID | NIH-10904005 on NIH RePORTER |
What this research studies
This research investigates the biomechanical properties of the human eye lens as it ages, focusing on how these properties affect lens shape and function. By examining the interactions between the lens fibers and the surrounding capsule, the study aims to uncover the mechanisms that lead to conditions like presbyopia and cataracts. The approach involves a novel theory of soft tissue growth, likening the lens to a gelatin-filled balloon, to better understand how these changes occur over time.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over the age of 21 who are experiencing age-related vision changes.
Not a fit: Patients with congenital eye conditions or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for age-related vision problems such as presbyopia and cataracts.
How similar studies have performed: Other research has shown promise in understanding lens biomechanics, but this specific approach is relatively novel.
Where this research is happening
Columbus, UNITED STATES
- Ohio State University — Columbus, United States (Active)
Researchers
- Principal investigator: Reilly, Matthew a — Ohio State University
- Study coordinator: Reilly, Matthew a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.