Understanding how the sense of smell works in Fragile X syndrome and autism
Mechanisms of olfactory signal processing
This project explores how the sense of smell is affected in mouse models of Fragile X syndrome, a common genetic cause of autism.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project ID | NIH-11063786 on NIH RePORTER |
What this research studies
Fragile X syndrome, a leading genetic cause of autism, often leads to difficulties with sensory processing, including how individuals experience smells. This project uses mouse models to investigate how a specific protein, FMRP, influences the brain's ability to process scents. By studying the connections and activity in the brain's smell center, known as the olfactory bulb, we aim to uncover the underlying causes of sensory challenges in Fragile X. This work could help explain why individuals with Fragile X and autism might experience hypersensitivity to certain smells.
Who could benefit from this research
Good fit: This foundational research is not directly recruiting patients but aims to benefit individuals with Fragile X syndrome and autism who experience sensory processing difficulties.
Not a fit: Patients without Fragile X syndrome or autism spectrum disorders are unlikely to directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to a better understanding of sensory processing issues in Fragile X syndrome and autism, potentially guiding future treatments.
How similar studies have performed: There have been few previous studies specifically looking at the sense of smell in mouse models of Fragile X syndrome, making this a novel area of exploration.
Where this research is happening
Aurora, UNITED STATES
- University of Colorado Denver — Aurora, United States (Active)
Researchers
- Principal investigator: Schoppa, Nathan Eric — University of Colorado Denver
- Study coordinator: Schoppa, Nathan Eric
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.