Understanding how the right ventricle fails
Multiscale mechanobiology of right ventricular failure
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA-IRVINE · NIH-11137165
This study is looking into why the right side of the heart sometimes fails to work properly, using computer models to understand the problem better, and it hopes to find new ways to help people with this condition since there aren't many treatments available right now.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA-IRVINE (nih funded) |
| Locations | 1 site (IRVINE, UNITED STATES) |
| Trial ID | NIH-11137165 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms behind right ventricular failure (RVF) using advanced computational modeling techniques. By analyzing dysfunction at various biological scales—from cellular to organ levels—the study aims to identify the underlying causes of RVF. The approach integrates data from healthy and RVF conditions to predict how abnormalities contribute to the overall heart function. This could lead to the development of targeted therapies for RVF, which currently lacks specific treatment options.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with right ventricular failure or those at risk of developing this condition.
Not a fit: Patients with left ventricular failure or those without any cardiac dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies specifically designed for patients suffering from right ventricular failure.
How similar studies have performed: While computational modeling has been successful in studying left ventricular failure, its application to right ventricular failure is relatively novel and untested.
Where this research is happening
IRVINE, UNITED STATES
- UNIVERSITY OF CALIFORNIA-IRVINE — IRVINE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CHESLER, NAOMI C — UNIVERSITY OF CALIFORNIA-IRVINE
- Study coordinator: CHESLER, NAOMI C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.