Understanding how the right ventricle adapts to high blood pressure in the lungs
Mechanisms of right ventricle adaptation to pulmonary hypertension
This study is looking at how the right side of the heart responds to high blood pressure in the lungs, especially in women, and it aims to find new ways to help improve heart function and blood flow for people dealing with this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | National Jewish Health NIH-funded |
| Lab location | 1 site (Denver, United States) |
| Project ID | NIH-10982346 on NIH RePORTER |
What this research studies
This research investigates how the right ventricle (RV) of the heart adapts to pulmonary hypertension (PH), focusing on the role of the NLRP3 inflammasome and the effects of the female sex hormone 17b-estradiol. The study aims to identify mechanisms that could lead to new therapies specifically targeting RV function, particularly in women. By using rat models, researchers will explore how inhibiting the NLRP3 inflammasome can improve heart function and blood flow in patients with RV failure. This work could pave the way for innovative treatments that enhance the quality of life for those affected by PH.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with pulmonary hypertension, particularly women who may experience different symptoms and outcomes.
Not a fit: Patients with pulmonary hypertension who do not have right ventricle dysfunction or those who are not female may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve heart function and survival rates for patients with pulmonary hypertension.
How similar studies have performed: Previous research has shown promise in targeting the NLRP3 inflammasome for heart conditions, suggesting that this approach could be effective, although this specific focus on RV adaptation in PH is relatively novel.
Where this research is happening
Denver, United States
- National Jewish Health — Denver, United States (Active)
Researchers
- Principal investigator: Lahm, Tim — National Jewish Health
- Study coordinator: Lahm, Tim
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.