Understanding how the Rift Valley fever virus packages its RNA
Official title: Investigation of RNA packaging in Rift Valley fever virus
Funded at University of Texas Med Br Galveston · NIH-11026820 · Data updated 2026-11-12
This study is looking at how the Rift Valley fever virus puts together its genetic material, which could help create better treatments and vaccines for people and animals affected by this virus, especially since it could spread to new areas like the U.S.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Med Br Galveston NIH-funded |
| Lab location | 1 site (Galveston, United States) |
| Project start | November 22, 2024 |
| Project end | October 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $636,101 |
| NIH project number | 1R01AI187192-01 |
| Project ID | NIH-11026820 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals at risk of RVFV infection, such as those living in endemic areas or working in agriculture.
✕Less likely to help
Patients who are not at risk of RVFV infection or those with existing immunity to the virus may not receive benefit from this research.
What this research studies
This research investigates the RNA packaging mechanisms of the Rift Valley fever virus (RVFV), which is transmitted by mosquitoes and can cause severe illness in humans and animals. By exploring the virus's genetic structure and how it assembles its RNA, the research aims to develop effective antiviral therapies and vaccines. The study is particularly important given the potential for RVFV outbreaks in non-endemic regions, including the U.S., and the lack of current vaccines or treatments. Patients may benefit from advancements in antiviral drugs and preventive measures against RVFV.
Why it matters
Potential benefit: If successful, this research could lead to the development of effective antiviral treatments and vaccines for Rift Valley fever, improving patient outcomes.
How similar studies have gone: Other research has shown success in developing antiviral therapies for similar viral infections, indicating a promising avenue for RVFV treatment.
Where this research is happening
-
University of Texas Med Br Galveston
Galveston, United States Active
Researchers
- Principal investigator: Makino, Shinji — University of Texas Med Br Galveston
- Study coordinator: Makino, Shinji
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.