Understanding how the RGS2 protein is controlled in the body
Posttranslational regulation of Regularo of G protein Signaling 2 (RGS2)
This research looks at how a protein called RGS2 works in our bodies, hoping to find new ways to help conditions like asthma and heart problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project ID | NIH-11117043 on NIH RePORTER |
What this research studies
RGS proteins help control important signals within our cells that affect many body functions. When levels of a specific RGS protein, called RGS2, are too low, it can contribute to conditions like high blood pressure, heart failure, and asthma. This project aims to understand exactly how the body naturally controls the amount and activity of RGS2. By discovering these natural control points, we hope to find new ways to develop medicines that can increase RGS2 levels and improve these conditions.
Who could benefit from this research
Good fit: This foundational research does not involve direct patient participation, but future studies stemming from this work could benefit patients with conditions linked to low RGS2, such as hypertension, heart failure, or asthma.
Not a fit: Patients whose conditions are not related to the function or levels of the RGS2 protein would likely not benefit from this specific line of research.
Why it matters
Potential benefit: If successful, this work could lead to new medications that increase RGS2 protein levels, potentially offering new treatments for conditions like hypertension, heart failure, and asthma.
How similar studies have performed: While RGS proteins are known to be important in disease, identifying specific mechanisms to regulate their activity and developing drugs for them remains a challenging and active area of investigation.
Where this research is happening
Irvine, United States
- University of California-Irvine — Irvine, United States (Active)
Researchers
- Principal investigator: Sjogren, Benita Jenny — University of California-Irvine
- Study coordinator: Sjogren, Benita Jenny
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.