Understanding how the retina adapts in degenerative eye diseases
Functional plasticity in retinal degenerative disease
This study is looking at how the cells in the eye change as we age or when there are diseases that cause vision loss, using a mouse model to find ways to improve vision even when some cells are damaged, with hopes of creating new treatments to help people see better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project ID | NIH-11080347 on NIH RePORTER |
What this research studies
This research investigates how retinal neurons change their properties and connections in response to aging and degenerative diseases, a process known as retinal plasticity. By studying a mouse model of a specific genetic condition that causes vision loss, the researchers aim to identify mechanisms that could enhance vision despite the loss of photoreceptors. The project focuses on understanding how these compensatory mechanisms work and their effects on light signaling in the retina. Ultimately, the goal is to develop therapies that can restore vision by leveraging these adaptive processes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing vision loss due to retinal degenerative diseases, particularly those with genetic conditions like retinitis pigmentosa.
Not a fit: Patients with non-degenerative eye conditions or those whose vision loss is not related to retinal plasticity may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve or restore vision for individuals with retinal degenerative diseases.
How similar studies have performed: Previous research has shown promise in understanding retinal plasticity and its potential for vision restoration, indicating that this approach may lead to significant advancements.
Where this research is happening
Salt Lake City, United States
- University of Utah — Salt Lake City, United States (Active)
Researchers
- Principal investigator: Vinberg, Frans — University of Utah
- Study coordinator: Vinberg, Frans
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.