Understanding how the renin-angiotensin system affects pregnancy outcomes.
Official title: Investigation of the renin-angiotensin system at the maternal-fetal interface.
Funded at Oregon Health & Science University · NIH-10936239 · Data updated 2026-11-12
This study is looking at how a protein called ACE2 affects pregnancy and could lead to problems like preeclampsia or losing a baby, with the goal of finding ways to help improve the health of both moms and their babies.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project start | September 16, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $493,409 |
| NIH project number | 1R01HD115535-01 |
| Project ID | NIH-10936239 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include pregnant individuals experiencing complications such as preeclampsia or unexplained pregnancy loss.
✕Less likely to help
Patients who are not pregnant or those with unrelated health conditions may not benefit from this research.
What this research studies
This research investigates the role of the renin-angiotensin system (RAS) at the maternal-fetal interface, focusing on how reduced levels of ACE2 protein can lead to complications during pregnancy. By using advanced techniques such as embryo transfer, blood pressure monitoring, and detailed morphological analyses, the study aims to uncover how disruptions in RAS contribute to issues like embryonic loss and preeclampsia. The findings could provide insights into the local mechanisms of placental development and fetal growth, which are crucial for improving maternal and fetal health.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and management of pregnancy complications, potentially improving outcomes for mothers and their babies.
How similar studies have gone: Previous studies have shown that targeting the renin-angiotensin system can lead to significant improvements in understanding and managing cardiovascular and pregnancy-related conditions, suggesting a promising avenue for this research.
Where this research is happening
-
Oregon Health & Science University
Portland, United States Active
Researchers
- Principal investigator: Vrooman, Lisa Anne — Oregon Health & Science University
- Study coordinator: Vrooman, Lisa Anne
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.