Understanding how the protective layers of the brain develop and their role in tumors
Official title: Investigating the Regulatory Logic Underlying Meningeal Development and Tumorigenesis
Funded at California Institute of Technology · NIH-11115429 · Data updated 2026-11-12
This study is looking at how the protective layers around the brain develop and how problems in this process can lead to conditions like Treacher Collins syndrome and craniosynostosis, with the hope of finding new ways to help those affected.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | California Institute of Technology NIH-funded |
| Lab location | 1 site (Pasadena, United States) |
| Project start | April 7, 2025 |
| Project end | March 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $162,281 |
| NIH project number | 1K99DE034827-01 |
| Project ID | NIH-11115429 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with craniofacial disorders such as Treacher Collins syndrome or craniosynostosis.
✕Less likely to help
Patients without craniofacial disorders or those not affected by neurocristopathies may not benefit from this research.
What this research studies
This research investigates the development of the cranial meninges, the protective layers surrounding the brain, and their role in craniofacial structures. It aims to uncover the gene regulatory networks involved in this process and how defects in these networks can lead to various disorders. By studying the early embryonic development of the meninges, the research seeks to understand the origins of conditions like Treacher Collins syndrome and craniosynostosis. Patients may benefit from insights into how these conditions arise and potential new therapeutic approaches.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for craniofacial disorders linked to meningeal development.
How similar studies have gone: While the specific focus on meningeal development is relatively novel, related research has shown success in understanding craniofacial disorders through genetic and developmental studies.
Where this research is happening
-
California Institute of Technology
Pasadena, United States Active
Researchers
- Principal investigator: Desingu Rajan, Ayyappa Raja — California Institute of Technology
- Study coordinator: Desingu Rajan, Ayyappa Raja
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.