Understanding how the protective layers of the brain develop and function
Mechanisms regulating Meningeal Development and Function
This study looks at the protective layers around the brain and spinal cord to see how they help keep our brains healthy by managing the fluid that cleans out waste, and it's using zebrafish to learn how things like age and diet might impact brain health and conditions like brain injuries.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project ID | NIH-11099727 on NIH RePORTER |
What this research studies
This research investigates the meninges, the protective layers surrounding the brain and spinal cord, focusing on their role in maintaining brain health by regulating cerebrospinal fluid (CSF). It aims to understand how these layers interact with blood vessels to clear metabolic waste, which is crucial for preventing neurodegeneration. Using zebrafish as a model, the study employs live imaging techniques to observe meningeal development and function in real-time. This approach allows researchers to explore how factors like age and diet may affect brain health and contribute to conditions such as acquired brain injury.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals aged 21 and older who may be experiencing neurodegenerative conditions or have suffered from acquired brain injuries.
Not a fit: Patients with acute neurological conditions unrelated to the mechanisms of meningeal function or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into preventing or treating neurodegenerative diseases by improving brain waste clearance mechanisms.
How similar studies have performed: Previous research has shown promising results in understanding brain health through similar approaches, particularly in animal models like zebrafish, indicating potential for success in this area.
Where this research is happening
Salt Lake City, United States
- University of Utah — Salt Lake City, United States (Active)
Researchers
- Principal investigator: Venero Galanternik, Marina — University of Utah
- Study coordinator: Venero Galanternik, Marina
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.