Understanding how the proteasome is assembled in cells
Investigation of the proteasome assembly landscape
This study is looking at how a key protein complex in our cells, which helps break down damaged proteins, is put together and whether it can be assembled in different ways depending on the cell's needs, with the hope that this could lead to better treatments for conditions like cancer and neurodegenerative diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Florida State University NIH-funded |
| Lab location | 1 site (Tallahassee, United States) |
| Project ID | NIH-10924037 on NIH RePORTER |
What this research studies
This research investigates the assembly of the 26S proteasome, a crucial protein complex responsible for degrading damaged or unnecessary proteins in cells. The researchers aim to explore whether there are multiple pathways for assembling this complex, rather than a single, rigid sequence. By examining how these assembly routes can adapt to changes in the cellular environment, the study seeks to uncover new insights that could lead to therapies for conditions like cancer and neurodegenerative diseases. Patients may benefit from advancements in treatments that target proteasome function based on these findings.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals diagnosed with cancer or neurodegenerative diseases.
Not a fit: Patients with conditions unrelated to proteasome function or those not experiencing protein degradation issues may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that enhance proteasome function, potentially improving treatment outcomes for patients with cancer and neurodegenerative disorders.
How similar studies have performed: While the concept of proteasome assembly is established, this specific investigation into the assembly landscape is novel and has not been extensively tested in prior research.
Where this research is happening
Tallahassee, United States
- Florida State University — Tallahassee, United States (Active)
Researchers
- Principal investigator: Tomko, Robert Joseph — Florida State University
- Study coordinator: Tomko, Robert Joseph
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.