Understanding how the proteasome, a protein complex, is formed and functions.
Structural and Functional Analysis of Proteasome Core Particle Biogenesis
This study is looking at how a key protein complex called the proteasome is made and works, which is important for breaking down damaged proteins that can cause diseases like Alzheimer's and cancer, and it hopes to find ways to make this process better to help patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11059862 on NIH RePORTER |
What this research studies
This research investigates the biogenesis of the proteasome, a crucial protein complex responsible for degrading misfolded proteins that can lead to diseases like Alzheimer's and cancer. By analyzing the structural and functional aspects of the proteasome's core particle, the study aims to uncover how this complex is assembled and how it can be enhanced to improve protein degradation. The approach involves creating specific mutants of the core particle to better understand the assembly process and identify potential therapeutic targets. Patients may benefit from insights gained about enhancing proteasome function to treat conditions related to protein misfolding.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with neurodegenerative diseases such as Alzheimer's or those with cancers that involve protein misfolding.
Not a fit: Patients with conditions unrelated to protein misfolding or those who do not have neurodegenerative diseases or cancers may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve the degradation of misfolded proteins, potentially benefiting patients with neurodegenerative diseases and certain cancers.
How similar studies have performed: Previous research has shown success in targeting proteasome function for therapeutic purposes, particularly in cancer treatment, indicating that this approach has potential.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Hanna, John W — Brigham and Women's Hospital
- Study coordinator: Hanna, John W
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.