Understanding how the placenta defends against viral infections during pregnancy
Innate immune signaling in placental antiviral defenses
This study is looking at how the placenta helps keep both moms and babies safe from harmful viruses, with the hope of finding new ways to protect pregnancies from infections that could cause problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project ID | NIH-10662462 on NIH RePORTER |
What this research studies
This research investigates the innate immune pathways in the placenta that help protect both the mother and fetus from harmful viral infections. By studying how the placenta senses and responds to these viruses, the researchers aim to uncover mechanisms that could prevent the transmission of infections from mother to baby. The project combines expertise in virology, immunology, and placental biology to identify specific immune responses that enhance antiviral defenses. This could lead to new strategies for safeguarding pregnancies against teratogenic viruses.
Who could benefit from this research
Good fit: Ideal candidates for this research are pregnant individuals who may be at risk of viral infections that could affect fetal development.
Not a fit: Patients who are not pregnant or those whose pregnancies are not at risk for viral infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention strategies for viral infections during pregnancy, ultimately protecting fetal development and maternal health.
How similar studies have performed: Previous studies have shown success in identifying immune pathways in the placenta, suggesting that this research builds on established findings rather than exploring entirely novel territory.
Where this research is happening
Durham, United States
- Duke University — Durham, United States (Active)
Researchers
- Principal investigator: Coyne, Carolyn B — Duke University
- Study coordinator: Coyne, Carolyn B
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.