Understanding how the pituitary gland adapts to hormonal changes
Official title: Molecular mechanisms of pituitary plasticity
Funded at Univ of Arkansas for Med Scis · NIH-11194428 · Data updated 2026-11-12
This study is looking at how a special protein called Musashi helps the pituitary gland adjust its hormone production based on the body's changing needs, which could lead to new treatments for hormone-related issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of Arkansas for Med Scis NIH-funded |
| Lab location | 1 site (Little Rock, United States) |
| Project start | September 18, 2024 |
| Project end | May 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $637,340 |
| NIH project number | 5R01DK139476-02 |
| Project ID | NIH-11194428 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include adults over 21 years old who are experiencing hormonal imbalances or related health issues.
✕Less likely to help
Patients with stable hormonal levels and no related health concerns may not benefit from this research.
What this research studies
This research investigates the molecular mechanisms that allow the anterior pituitary gland to adapt its hormone production in response to changing metabolic and reproductive needs. By focusing on a protein called Musashi, which plays a crucial role in regulating cell function, the research aims to uncover how this protein influences the fate of hormone-producing cells. The study employs advanced techniques in bioinformatics and cellular analysis to identify the pathways involved in this plasticity. The findings could lead to new therapeutic strategies for conditions related to hormonal imbalances.
Why it matters
Potential benefit: If successful, this research could provide new insights into treatments for hormonal disorders and cancer progression.
How similar studies have gone: Previous research has shown success in understanding cellular plasticity in other tissues, suggesting potential for breakthroughs in this area as well.
Where this research is happening
-
Univ of Arkansas for Med Scis
Little Rock, United States Active
Researchers
- Principal investigator: Macnicol, Angus M — Univ of Arkansas for Med Scis
- Study coordinator: Macnicol, Angus M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.