Understanding how the PI3K and AKT pathways contribute to cancer
Discovery, Regulation and Function of the PI 3-Kinase and AKT Pathway in Cancer
This study is looking at important pathways in cancer cells to find new ways to treat cancer, and it could help patients by discovering better treatments for their specific types of cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beth Israel Deaconess Medical Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10883682 on NIH RePORTER |
What this research studies
This research investigates the PI3K and AKT signaling pathways, which are crucial in the development and progression of various cancers. By utilizing advanced techniques such as CRISPR-based screens, the study aims to uncover new vulnerabilities in these pathways that could be targeted for therapeutic purposes. The research focuses on understanding how these pathways regulate cancer cell behaviors like growth, survival, and movement. Patients may benefit from insights that could lead to more effective treatments for their cancers.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with cancers that are known to involve the PI3K/AKT signaling pathways.
Not a fit: Patients with cancers unrelated to the PI3K/AKT pathways may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new therapies that more effectively target cancer cells by exploiting their reliance on the PI3K/AKT pathways.
How similar studies have performed: Previous research has shown promise in targeting the PI3K/AKT pathways, but this specific approach aims to uncover novel vulnerabilities that have not yet been fully explored.
Where this research is happening
Boston, United States
- Beth Israel Deaconess Medical Center — Boston, United States (Active)
Researchers
- Principal investigator: Toker, Alex — Beth Israel Deaconess Medical Center
- Study coordinator: Toker, Alex
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.