Understanding how the physical properties of materials affect cell behavior
Leveraging protein-engineered biomaterials and bioorthogonal chemistries to elucidate the role of non-elastic matrix properties in regulating cell fate
['FUNDING_OTHER'] · UNIVERSITY OF PENNSYLVANIA · NIH-10939499
This study is looking at how the environment around our cells affects their behavior, which could help us understand how to improve healing and treat diseases better.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PENNSYLVANIA (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-10939499 on ClinicalTrials.gov |
What this research studies
This research investigates how cells respond to the mechanical properties of their environment, particularly focusing on the extracellular matrix (ECM) that surrounds them. By creating advanced biomaterials that can mimic these properties, the study aims to uncover the molecular mechanisms that influence cell functions such as adhesion, migration, and division. The approach involves using engineered systems that can independently control various mechanical parameters, allowing for a clearer understanding of how these factors affect cellular behavior in health and disease. Patients may benefit from insights gained about tissue regeneration and disease progression.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to tissue regeneration or diseases influenced by cellular mechanics.
Not a fit: Patients with conditions unrelated to cellular mechanics or tissue regeneration may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for tissue regeneration and better understanding of disease mechanisms.
How similar studies have performed: Previous research has shown promising results in understanding cellular responses to mechanical properties, indicating that this approach has potential for success.
Where this research is happening
PHILADELPHIA, UNITED STATES
- UNIVERSITY OF PENNSYLVANIA — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MADL, CHRISTOPHER MATTHEW — UNIVERSITY OF PENNSYLVANIA
- Study coordinator: MADL, CHRISTOPHER MATTHEW
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.