Understanding how the PAXT complex recognizes RNA molecules in cells
Recognition of ribonucleoprotein (RNP) substrate by the poly(A) exosome targeting (PAXT) complex
This study is looking at how a special protein complex in our cells helps manage RNA, which is important for cell health, and it hopes to find new ways to treat diseases like cholangiocarcinoma by understanding these processes better.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10543559 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which the poly(A) exosome targeting (PAXT) complex identifies and processes ribonucleoprotein (RNP) substrates in the cell nucleus. By utilizing biochemical and structural biology techniques, the study aims to characterize the PAXT complex and its interactions with RNA molecules, particularly focusing on how these processes may contribute to diseases like cholangiocarcinoma. Patients may benefit from insights gained about RNA degradation pathways, which could lead to new therapeutic strategies. The research will also explore the role of microRNA processing in cellular health.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with cholangiocarcinoma or those with related RNA processing disorders.
Not a fit: Patients with conditions unrelated to RNA processing or those not diagnosed with cholangiocarcinoma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for cholangiocarcinoma and other diseases linked to RNA processing.
How similar studies have performed: Previous research has shown promise in understanding RNA surveillance mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
New York, United States
- Sloan-Kettering Inst Can Research — New York, United States (Active)
Researchers
- Principal investigator: Park, Mi Seul — Sloan-Kettering Inst Can Research
- Study coordinator: Park, Mi Seul
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.