Understanding how the pancreas environment affects insulin-producing cells in Type 1 Diabetes
The Role of the Pancreas Microenvironment in Regulating Islet Function and Survival in Type 1 Diabetes
This project explores how changes in the pancreas surrounding insulin-making cells might contribute to Type 1 Diabetes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Colorado School of Mines NIH-funded |
| Lab location | 1 site (Golden, United States) |
| Project ID | NIH-11126679 on NIH RePORTER |
What this research studies
We know that in Type 1 Diabetes, the body's immune system attacks and destroys insulin-producing cells. Before this destruction, the protective layer around these cells in the pancreas often breaks down. Our work suggests that stressed insulin-producing cells might themselves release enzymes that damage this protective layer, making it easier for immune cells to attack. We are looking at how losing this protective layer affects the health and function of these vital cells, which could help us understand how Type 1 Diabetes develops.
Who could benefit from this research
Good fit: This foundational work is for anyone interested in the underlying causes of Type 1 Diabetes, particularly those in early stages or at risk.
Not a fit: Patients with advanced Type 1 Diabetes who have already experienced significant loss of insulin-producing cells may not directly benefit from this early-stage research.
Why it matters
Potential benefit: If successful, this work could lead to new ways to protect insulin-producing cells and potentially prevent or slow the progression of Type 1 Diabetes.
How similar studies have performed: While the specific mechanisms are still being uncovered, other studies have highlighted the importance of the cellular environment in disease progression.
Where this research is happening
Golden, United States
- Colorado School of Mines — Golden, United States (Active)
Researchers
- Principal investigator: Farnsworth, Nikki L. — Colorado School of Mines
- Study coordinator: Farnsworth, Nikki L.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.