Understanding how the pancreas changes in type 1 diabetes
Co-registration of Cell Organization, Phenotype and Function in the Human Pancreas During Type 1 Diabetes
This study is looking at how type 1 diabetes affects the pancreas and its cells, aiming to understand the immune response and how these cells work together, so we can find new ways to help people with this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project ID | NIH-10880302 on NIH RePORTER |
What this research studies
This research investigates the complex changes in the human pancreas associated with type 1 diabetes (T1D), focusing on the immune response and the function of pancreatic cells. By examining both islet and acinar cells, the study aims to uncover how these cells interact and contribute to the disease's progression. Using advanced techniques like single-cell RNA sequencing, researchers will analyze pancreatic tissue samples from individuals with T1D, those at risk, and healthy donors to identify key functional and molecular changes. This comprehensive approach seeks to provide insights into the mechanisms behind T1D and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with type 1 diabetes, those at risk of developing the condition, and healthy organ donors.
Not a fit: Patients with type 2 diabetes or other unrelated pancreatic conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients with type 1 diabetes.
How similar studies have performed: Other research has shown promising results in understanding pancreatic function in diabetes, making this approach both relevant and potentially impactful.
Where this research is happening
Gainesville, United States
- University of Florida — Gainesville, United States (Active)
Researchers
- Principal investigator: Atkinson, Mark a. — University of Florida
- Study coordinator: Atkinson, Mark a.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.