Understanding how the P2Y10 receptor affects Sjögren’s disease
Official title: lluminating the Role of the Novel G Protein-Coupled P2Y10 Receptor in Sjögren’s Disease Pathophysiology
Funded at University of Louisville · NIH-11216814 · Data updated 2026-11-12
This study is looking at how a specific receptor in the body, called the P2Y10 receptor, affects Sjögren’s disease, which causes dry eyes and mouth, to help us understand the disease better and find new ways to treat it.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Louisville NIH-funded |
| Lab location | 1 site (Louisville, United States) |
| Project start | March 1, 2025 |
| Project end | February 28, 2026 |
| Funding year | 2025 |
| Award (this year) | $135,765 |
| NIH project number | 7R03DE033729-02 |
| Project ID | NIH-11216814 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Sjögren’s disease, particularly those experiencing systemic symptoms.
✕Less likely to help
Patients with non-autoimmune conditions or those not diagnosed with Sjögren’s disease may not benefit from this research.
What this research studies
This research investigates the role of the P2Y10 receptor in Sjögren’s disease, an autoimmune condition that causes dry eyes and mouth. By examining how different forms of lysophosphatidylserine (LysoPS) interact with this receptor, the study aims to clarify its immunomodulatory functions and how they relate to the disease's progression. The research will utilize advanced methodologies to determine the specificity of P2Y10 receptor ligands and their impact on immune responses in Sjögren’s disease. This could lead to a better understanding of the disease mechanisms and potential therapeutic targets.
Why it matters
Potential benefit: If successful, this research could lead to new treatment strategies for patients with Sjögren’s disease.
How similar studies have gone: While the specific role of the P2Y10 receptor in Sjögren’s disease is relatively novel, similar research on other G protein-coupled receptors has shown promising results in understanding autoimmune diseases.
Where this research is happening
-
University of Louisville
Louisville, United States Active
Researchers
- Principal investigator: Jasmer, Kimberly J — University of Louisville
- Study coordinator: Jasmer, Kimberly J
Related research
Other NIH-funded projects on the same topics.
-
Understanding CAG repeat instability in Huntington’s disease
A Huntington’s disease study explores why the CAG repeat in the HTT gene becomes unstable and leads to earlier disease, aiming to uncover factors that influence when and how the disease starts.
-
Understanding how brain activity changes may drive Alzheimer’s disease progression in a mouse model
Researchers are testing how changes in brain signals and protein cleanup processes affect the development of Alzheimer’s disease in mice.
-
Thiamine-boosting therapy for Alzheimer’s: understanding how benfotiamine may reduce harmful AGE in DP patients
A medication-based approach using high-dose vitamin B1 (benfotiamine) is studied to help people with Alzheimer's by reducing harmful sugar-related molecules.
-
Non-invasive tears biomarker for early Alzheimer's in LMICs
A low-cost, tear-based biomarker approach aims to detect early Alzheimer’s disease in older adults in Peru and similar settings.
-
Turning APOE4 into protective APOE2 or APOE3Christchurch to help with Alzheimer’s
A patient-facing explanation of a treatment idea that aims to change a genetic risk factor for Alzheimer's disease in the brain.
-
Telomerase in Alzheimer’s Disease: how aging biology could influence memory and brain health
Researchers are exploring a new brain-aging mechanism linked to telomerase, with potential to slow or modify Alzheimer’s disease in people and improve cognitive function.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.