Understanding how the P2Y10 receptor affects Sjögren’s disease
lluminating the Role of the Novel G Protein-Coupled P2Y10 Receptor in Sjögren’s Disease Pathophysiology
['FUNDING_R03'] · UNIVERSITY OF LOUISVILLE · NIH-11216814
This study is looking at how a specific receptor in the body, called the P2Y10 receptor, affects Sjögren’s disease, which causes dry eyes and mouth, to help us understand the disease better and find new ways to treat it.
Quick facts
| Phase | ['FUNDING_R03'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF LOUISVILLE (nih funded) |
| Locations | 1 site (LOUISVILLE, UNITED STATES) |
| Trial ID | NIH-11216814 on ClinicalTrials.gov |
What this research studies
This research investigates the role of the P2Y10 receptor in Sjögren’s disease, an autoimmune condition that causes dry eyes and mouth. By examining how different forms of lysophosphatidylserine (LysoPS) interact with this receptor, the study aims to clarify its immunomodulatory functions and how they relate to the disease's progression. The research will utilize advanced methodologies to determine the specificity of P2Y10 receptor ligands and their impact on immune responses in Sjögren’s disease. This could lead to a better understanding of the disease mechanisms and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Sjögren’s disease, particularly those experiencing systemic symptoms.
Not a fit: Patients with non-autoimmune conditions or those not diagnosed with Sjögren’s disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment strategies for patients with Sjögren’s disease.
How similar studies have performed: While the specific role of the P2Y10 receptor in Sjögren’s disease is relatively novel, similar research on other G protein-coupled receptors has shown promising results in understanding autoimmune diseases.
Where this research is happening
LOUISVILLE, UNITED STATES
- UNIVERSITY OF LOUISVILLE — LOUISVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: JASMER, KIMBERLY J — UNIVERSITY OF LOUISVILLE
- Study coordinator: JASMER, KIMBERLY J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Addison's disease