Understanding how the outer layer of organs changes during development
Developmentally Programmed Remodeling of Apical ECM
This study is exploring a special layer that covers our organs, called the apical extracellular matrix, to understand how it helps organs grow and work properly, which could lead to new ways to treat diseases and improve tissue repair.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10982505 on NIH RePORTER |
What this research studies
This research investigates the apical extracellular matrix (aECM), a dynamic layer that coats the surfaces of organs and plays a crucial role in organ development and function. By studying the regulatory mechanisms that control the composition and structure of aECM, the research aims to uncover how it influences cell behavior and organ morphogenesis. The project utilizes innovative models to visualize and analyze aECM remodeling in living organisms, particularly focusing on the C. elegans cuticle as a model system. This approach could lead to new strategies for therapeutic delivery and tissue engineering.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with developmental disorders or conditions affecting organ function.
Not a fit: Patients with stable, non-progressive conditions that do not involve developmental changes in organ structure may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to advancements in targeted therapies and improved tissue engineering techniques for various medical conditions.
How similar studies have performed: Other research has shown success in manipulating extracellular matrices for therapeutic purposes, indicating potential for this approach.
Where this research is happening
Boston, United States
- Boston Children's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Heiman, Maxwell — Boston Children's Hospital
- Study coordinator: Heiman, Maxwell
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.