Understanding how the olfactory system develops and adapts in mammals
Mechanisms of Developmental Plasticity in the Mammalian Olfactory System
This study is looking at how the sense of smell develops in young mammals right after they are born, focusing on how certain proteins help the brain's smell neurons adapt to their surroundings, which could help us understand more about how our sense of smell works.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-11048469 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind the developmental plasticity of olfactory sensory neurons (OSNs) in mammals, particularly focusing on a critical period shortly after birth. The study aims to understand how these neurons can change and adapt their connections in response to environmental stimuli during early development. By using a combination of genetic manipulation, imaging techniques, and behavioral assays, researchers will explore the role of a specific protein, Fzd1, in regulating this plasticity. The findings could shed light on how the olfactory system develops and how it might be influenced by various factors.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would be individuals under 21 years old, particularly those experiencing developmental challenges or neurodevelopmental disorders.
Not a fit: Patients over 21 years old or those with established neurodegenerative conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into how to enhance neural plasticity, which may have implications for treating neurodevelopmental disorders.
How similar studies have performed: Previous research has shown promising results in understanding neural plasticity in other systems, suggesting that this approach could yield valuable insights.
Where this research is happening
Cleveland, United States
- Case Western Reserve University — Cleveland, United States (Active)
Researchers
- Principal investigator: Yu, Congrong Ron — Case Western Reserve University
- Study coordinator: Yu, Congrong Ron
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.