Understanding how the nucleolus affects genome organization in health and disease
The role of the nucleolus in human genome organization in normal and disease states
This study is looking at a part of our cells called the nucleolus, which helps make important building blocks for our cells and keeps our genetic material organized, to see how it works differently in cancer cells, with the hope of finding new ways to treat cancer.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of Massachusetts Med Sch Worcester NIH-funded |
| Lab location | 1 site (Worcester, United States) |
| Project ID | NIH-10918273 on NIH RePORTER |
What this research studies
This research investigates the nucleolus, a key cellular structure involved in the production of ribosomes and the organization of genetic material within the nucleus. By examining how the nucleolus interacts with specific DNA regions, the study aims to uncover its role in maintaining proper chromosome function and how these interactions change in cancer cells. The research employs advanced techniques to visualize and analyze these cellular processes, which could lead to new insights into cancer biology and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with cancer or those at risk for developing cancer due to genetic factors.
Not a fit: Patients with non-cancerous conditions unrelated to nucleolar function may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding of cancer mechanisms and the development of novel treatments.
How similar studies have performed: Previous research has shown promising results in understanding nucleolar functions in cancer, indicating that this approach has potential for significant findings.
Where this research is happening
Worcester, United States
- Univ of Massachusetts Med Sch Worcester — Worcester, United States (Active)
Researchers
- Principal investigator: Kaufman, Paul D. — Univ of Massachusetts Med Sch Worcester
- Study coordinator: Kaufman, Paul D.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.