Understanding how the nuclear pore controls transport in disease-related cancers
Official title: Structure-Function Mapping of the Nuclear Pore Complex-Renewal
Funded at Rockefeller University · NIH-11399792 · Data updated 2026-11-12
A senior scientist at Rockefeller University is mapping how the nuclear pore complex works to move molecules in and out of the cell, with potential implications for cancers.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rockefeller University NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | March 1, 2015 |
| Project end | August 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $668,770 |
| NIH project number | 5R01GM112108-12 |
| Project ID | NIH-11399792 on NIH RePORTER |
Who could benefit from this research
✓Could help
Not applicable to patients in its current stage; foundational discoveries may later inform cancer-related trials.
✕Less likely to help
No direct patient treatment or trial participation is involved in this basic science project at this time.
What this research studies
This project builds detailed maps of the nuclear pore complex to understand how its structure changes during different functional states. The team will link structural information with functional outcomes to create working models of how transport is regulated in cells. Although the focus is on basic biology in yeast, the insights could illuminate cancer cell behavior where transport processes are disrupted. By combining structural analysis with functional state mapping, researchers aim to uncover mechanistic links between NPC architecture and its roles in cell physiology and chromatin regulation.
Why it matters
Potential benefit: Insights from this work could advance our understanding of cancer cell biology and identify new angles for therapies targeting cellular transport processes.
How similar studies have gone: Previous NPC structural work has led to deeper mechanistic models; this project advances from static maps to functional-state models.
Where this research is happening
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Rockefeller University
New York, United States Active
Researchers
- Principal investigator: Rout, Michael P — Rockefeller University
- Study coordinator: Rout, Michael P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.