Understanding how the nuclear envelope changes during cell division and its impact on diseases.
Dynamic Events at the Nuclear Envelope during Mitosis and Interphase
This study looks at how the outer layer of our cells changes during cell division and rest, and how these changes might affect our DNA and lead to diseases like cancer, with the hope of finding better treatments for age-related illnesses.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project ID | NIH-10802853 on NIH RePORTER |
What this research studies
This research investigates the dynamic changes that occur at the nuclear envelope during cell division and interphase, focusing on how these changes affect genomic stability and contribute to diseases, particularly cancers. By examining the roles of specific proteins and structures within the nuclear envelope, the study aims to uncover mechanisms that could lead to better understanding and potential treatments for aging-associated diseases. The research employs advanced imaging techniques to observe the nuclear envelope in real-time, providing insights into its structural adaptations and functions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a family history of cancer or those diagnosed with aging-associated diseases that may involve genomic instability.
Not a fit: Patients with conditions unrelated to nuclear envelope integrity or those who are not experiencing aging-associated diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating cancers and other diseases linked to nuclear envelope dysfunction.
How similar studies have performed: Previous research has shown that understanding cellular structures like the nuclear envelope can lead to significant advancements in cancer treatment, indicating that this approach has potential for success.
Where this research is happening
Salt Lake City, United States
- University of Utah — Salt Lake City, United States (Active)
Researchers
- Principal investigator: Ullman, Katharine S — University of Utah
- Study coordinator: Ullman, Katharine S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.