Understanding how the notochord in zebrafish supports spine development
Investigating the Mechanical Properties of Vertebrate Notochord in Zebrafish
['FUNDING_FELLOWSHIP'] · DUKE UNIVERSITY · NIH-10992500
This study is looking at how a key part of the spine, called the notochord, works in zebrafish to help us understand how spines develop and what might go wrong, which could be helpful for people with spine issues.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | DUKE UNIVERSITY (nih funded) |
| Locations | 1 site (DURHAM, UNITED STATES) |
| Trial ID | NIH-10992500 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanical properties of the notochord, a vital structure in vertebrates that supports the spine during development. By using zebrafish as a model organism, the study will explore how the notochord's unique vacuolated cells respond to mechanical stresses and contribute to the formation of vertebrae. The research employs advanced techniques such as acute mechanical stress application and genetic manipulation to observe the notochord's behavior under various conditions. This work aims to deepen our understanding of spinal development and potential deformities.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with congenital spinal deformities or those interested in the biological mechanisms of spine development.
Not a fit: Patients with acquired spinal injuries or conditions unrelated to developmental biology may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into spinal deformities and inform future treatments for related conditions.
How similar studies have performed: While the specific focus on zebrafish notochord mechanics is novel, related studies have shown success in understanding vertebrate development through similar methodologies.
Where this research is happening
DURHAM, UNITED STATES
- DUKE UNIVERSITY — DURHAM, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ZAREIESFANDABADI, PARSA — DUKE UNIVERSITY
- Study coordinator: ZAREIESFANDABADI, PARSA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.