Understanding how the notochord in zebrafish supports spine development
Official title: Investigating the Mechanical Properties of Vertebrate Notochord in Zebrafish
Funded at Duke University · NIH-10992500 · Data updated 2026-11-12
This study is looking at how a key part of the spine, called the notochord, works in zebrafish to help us understand how spines develop and what might go wrong, which could be helpful for people with spine issues.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $42,002 |
| NIH project number | 1F31HD114438-01A1 |
| Project ID | NIH-10992500 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with congenital spinal deformities or those interested in the biological mechanisms of spine development.
✕Less likely to help
Patients with acquired spinal injuries or conditions unrelated to developmental biology may not benefit from this research.
What this research studies
This research investigates the mechanical properties of the notochord, a vital structure in vertebrates that supports the spine during development. By using zebrafish as a model organism, the study will explore how the notochord's unique vacuolated cells respond to mechanical stresses and contribute to the formation of vertebrae. The research employs advanced techniques such as acute mechanical stress application and genetic manipulation to observe the notochord's behavior under various conditions. This work aims to deepen our understanding of spinal development and potential deformities.
Why it matters
Potential benefit: If successful, this research could lead to new insights into spinal deformities and inform future treatments for related conditions.
How similar studies have gone: While the specific focus on zebrafish notochord mechanics is novel, related studies have shown success in understanding vertebrate development through similar methodologies.
Where this research is happening
-
Duke University
Durham, United States Active
Researchers
- Principal investigator: Zareiesfandabadi, Parsa — Duke University
- Study coordinator: Zareiesfandabadi, Parsa
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.