Understanding how the non-coding parts of our genome regulate gene expression
Elucidation of the organizing principles of the regulatory genome through large-scale data integration
This study is looking at parts of our DNA that don't code for proteins but help control how our genes work, and it's for anyone interested in understanding how these areas might affect health and diseases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Altius Institute for Biomedical Sciences NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-10888255 on NIH RePORTER |
What this research studies
This research investigates the complex roles of non-coding regions in the human genome, which are crucial for regulating gene expression but are not well understood. By integrating large-scale data from various sources, the project aims to uncover the patterns and principles governing these regulatory elements. This approach will help researchers analyze data collectively rather than in isolation, potentially revealing new insights into how genes are controlled in different cell types. The findings could enhance our understanding of genetic variations associated with diseases and traits.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic disorders or those interested in understanding the genetic basis of their health conditions.
Not a fit: Patients with conditions unrelated to genetic regulation or those not interested in genetic research may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding of genetic factors in diseases, paving the way for better diagnostic and therapeutic strategies.
How similar studies have performed: Previous research has shown success in understanding gene regulation through large-scale data integration, indicating that this approach has the potential for significant breakthroughs.
Where this research is happening
Seattle, United States
- Altius Institute for Biomedical Sciences — Seattle, United States (Active)
Researchers
- Principal investigator: Meuleman, Wouter — Altius Institute for Biomedical Sciences
- Study coordinator: Meuleman, Wouter
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.