Understanding how the Neuroligin-4 gene affects human brain cells
Cellular Mechanisms of Neuroligin-4 Gene in Human Neurons
This study is looking at a gene called Neuroligin-4 to see how it helps brain cells connect and communicate, using human stem cells to get a clearer picture of its role, which could help us understand more about brain function and related conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Colorado State University NIH-funded |
| Lab location | 1 site (Fort Collins, United States) |
| Project ID | NIH-10984965 on NIH RePORTER |
What this research studies
This research investigates the role of the Neuroligin-4 gene, which is important for cell adhesion in the human brain. By using human stem cells, the researchers aim to explore how this gene influences the organization of synapses, which are critical for communication between neurons. The study employs advanced genetic engineering techniques to create human neuronal models, allowing for a better understanding of the unique properties of Neuroligin-4 that are not present in traditional animal models. The findings could reveal important insights into brain function and potential implications for neurological conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with neurological conditions that may be linked to synaptic abnormalities.
Not a fit: Patients with conditions unrelated to synaptic function or those who do not have neurological disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into brain disorders and potential therapeutic targets for conditions related to synaptic dysfunction.
How similar studies have performed: While the specific approach of using human stem cells to study Neuroligin-4 is relatively novel, similar studies have shown promise in understanding other cell adhesion molecules in the brain.
Where this research is happening
Fort Collins, United States
- Colorado State University — Fort Collins, United States (Active)
Researchers
- Principal investigator: Chanda, Soham — Colorado State University
- Study coordinator: Chanda, Soham
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.