Understanding how the neural crest genome develops and functions
Official title: Architecture and function of the neural crest genome
Funded at Boston Children's Hospital · NIH-11061922 · Data updated 2026-11-12
This study is looking into how certain proteins help shape important cells during early development, which could lead to better ways to diagnose birth defects related to these cells, making it helpful for families affected by such conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | April 1, 2024 |
| Project end | February 28, 2029 |
| Funding year | 2025 |
| Award (this year) | $554,035 |
| NIH project number | 5R01DE033701-02 |
| Project ID | NIH-11061922 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with congenital malformations, particularly those related to craniofacial development.
✕Less likely to help
Patients without congenital malformations or those not affected by neural crest-related conditions may not benefit from this research.
What this research studies
This research investigates the neural crest, a group of stem cells crucial for forming various tissues and organs during embryonic development. It aims to uncover the molecular mechanisms that govern neural crest formation, particularly focusing on how architectural proteins like CTCF and YY1 influence gene regulation through chromatin organization. By employing advanced techniques such as chromatin conformation capture, the research will explore the interactions between these proteins and transcription factors to better understand their roles in neural crest development. This knowledge could lead to improved diagnostic methods for congenital malformations linked to neural crest disruptions.
Why it matters
Potential benefit: If successful, this research could enhance the understanding and diagnosis of craniofacial defects and other congenital malformations.
How similar studies have gone: Previous research has shown promising results in understanding gene regulation through chromatin architecture, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Boston Children's Hospital
Boston, United States Active
Researchers
- Principal investigator: Simoes-Costa, Marcos — Boston Children's Hospital
- Study coordinator: Simoes-Costa, Marcos
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.