Understanding how the nervous system in the gut develops
Genetic and extrinsic mechanisms governing early enteric nervous system development
This study is looking at how genes and other factors affect the development of the nervous system in the gut, using zebrafish embryos to see how nerve cells form, with the hope of finding new ways to help people with gut issues like Hirschsprung disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rice University NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-11036328 on NIH RePORTER |
What this research studies
This research investigates the genetic and external factors that influence the development of the enteric nervous system (ENS), which is crucial for gut function. By studying zebrafish embryos, researchers can observe the migration and differentiation of enteric neural progenitors (ENPs) in real-time. The goal is to uncover the mechanisms that lead to conditions like Hirschsprung disease, where parts of the gut lack proper nerve cells. This knowledge could pave the way for new treatments for gastrointestinal disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with congenital gastrointestinal conditions, particularly those affected by Hirschsprung disease.
Not a fit: Patients with gastrointestinal disorders not related to nerve development or those without congenital conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved therapies for patients with gastrointestinal disorders caused by nerve development issues.
How similar studies have performed: Previous research has shown promise in understanding similar developmental processes in model organisms, suggesting potential for breakthroughs in this area.
Where this research is happening
Houston, United States
- Rice University — Houston, United States (Active)
Researchers
- Principal investigator: Uribe, Rosa a — Rice University
- Study coordinator: Uribe, Rosa a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.