Understanding how the nervous system develops and functions in engineered human intestines.
Enteric Nervous System Development and Function in Human Intestinal Organoids
['FUNDING_CAREER'] · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · NIH-11094141
This study is looking at how to grow healthy pieces of intestine in the lab to help kids with intestinal problems, focusing on how certain receptors in the gut affect its health and function.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON (nih funded) |
| Locations | 1 site (HOUSTON, UNITED STATES) |
| Trial ID | NIH-11094141 on ClinicalTrials.gov |
What this research studies
This research investigates the development and function of the enteric nervous system (ENS) in human intestinal organoids, which are lab-grown tissues that mimic the human intestine. The study aims to identify the processes necessary for creating functional tissue-engineered intestines, which could serve as a treatment for children with intestinal failure. By examining the role of serotonin receptors in the ENS, the research will explore how these receptors influence intestinal health and function. Patients may benefit from advancements in treatments for intestinal disorders through this innovative approach.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 0-11 years who are experiencing intestinal failure or related gastrointestinal disorders.
Not a fit: Patients with fully functional intestines or those outside the pediatric age range may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for children suffering from intestinal failure, potentially improving their quality of life.
How similar studies have performed: Previous research has shown promise in using tissue-engineered models to study intestinal functions, indicating potential for success in this novel approach.
Where this research is happening
HOUSTON, UNITED STATES
- UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON — HOUSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SPEER, ALLISON LEIGH — UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
- Study coordinator: SPEER, ALLISON LEIGH
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.