Understanding how the nervous system adjusts to sudden sounds
Cellular and molecular analysis of startle modulation
This study looks at how the nervous system helps us react to loud noises, using zebrafish to understand why some people, especially those with ADHD or autism, might respond differently to sudden sounds, and it hopes to find genetic clues that explain these differences.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11017820 on NIH RePORTER |
What this research studies
This research investigates how the nervous system modulates responses to sudden and intense sounds, focusing on the startle response in vertebrates. By using zebrafish as a model organism, the study examines the molecular mechanisms that influence how these responses can change based on context, such as repeated exposure to startling stimuli. The research aims to uncover genetic factors that affect behavioral responses, particularly in individuals with neuropsychiatric disorders like ADHD and autism spectrum disorders. Through genetic screening, the team has identified specific mutants that show differences in their startle responses, which could lead to new insights into behavioral plasticity.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with ADHD or autism spectrum disorders.
Not a fit: Patients without neuropsychiatric disorders or those not exhibiting startle response issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for individuals with ADHD and autism spectrum disorders.
How similar studies have performed: Previous research has shown success in using zebrafish to study behavioral responses, indicating that this approach is promising.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Granato, Michael — University of Pennsylvania
- Study coordinator: Granato, Michael
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.