Understanding how the Nairovirus translates its genetic material
Official title: Demonstrating the mechanism of Nairovirus translation strategy
Funded at Western University of Health Sciences · NIH-10291623 · Data updated 2026-11-12
This study is looking at how the Crimean-Congo hemorrhagic fever virus works, especially focusing on a specific protein that helps the virus make copies of itself, with the hope of finding new ways to treat this serious illness for patients.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Western University of Health Sciences NIH-funded |
| Lab location | 1 site (Pomona, United States) |
| Project start | August 1, 2021 |
| Project end | July 31, 2025 |
| Funding year | 2021 |
| Award (this year) | $423,000 |
| NIH project number | 1R15AI154949-01A1 |
| Project ID | NIH-10291623 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who are at risk of exposure to the Crimean-Congo hemorrhagic fever virus, particularly those in endemic regions.
✕Less likely to help
Patients who are not at risk of Crimean-Congo hemorrhagic fever or those with other unrelated viral infections may not benefit from this research.
What this research studies
This research investigates the translation mechanism of the Crimean-Congo hemorrhagic fever virus, a highly contagious viral illness with no current treatment options. The study focuses on the nucleocapsid protein of the virus, which has distinct RNA binding sites that play a crucial role in the translation of the virus's genetic material. By examining how this protein interacts with viral RNA, the research aims to uncover potential targets for therapeutic intervention. Patients may benefit from insights gained that could lead to the development of effective treatments for this severe disease.
Why it matters
Potential benefit: If successful, this research could lead to the development of new treatments for Crimean-Congo hemorrhagic fever, significantly improving patient outcomes.
How similar studies have gone: While the specific mechanisms of Nairovirus translation are being explored in this research, similar studies on viral translation strategies have shown promise in identifying potential therapeutic targets.
Where this research is happening
-
Western University of Health Sciences
Pomona, United States Active
Researchers
- Principal investigator: Mir, Mohammad a — Western University of Health Sciences
- Study coordinator: Mir, Mohammad a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.