Understanding how the microbiota affects infections like chlamydia and gonorrhea
Host-Microbiota Interactions and STI Outcomes
['FUNDING_OTHER'] · UNIVERSITY OF MARYLAND BALTIMORE · NIH-11290895
This study is looking at how the natural balance of bacteria in the vagina can affect how the body responds to infections like chlamydia and gonorrhea, with the hope of helping patients understand their own health better.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MARYLAND BALTIMORE (nih funded) |
| Locations | 1 site (BALTIMORE, UNITED STATES) |
| Trial ID | NIH-11290895 on ClinicalTrials.gov |
What this research studies
This research focuses on creating a biomimetic model of the cervicovaginal environment to explore how interactions between the host and microbiota influence responses to infections caused by Chlamydia trachomatis and Neisseria gonorrhoeae. By utilizing advanced techniques such as RNA sequencing and immune profiling, the study aims to gain insights into the biological mechanisms at play during these infections. Patients may benefit from a better understanding of how their microbiota can affect their susceptibility to sexually transmitted infections.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are at risk for or currently experiencing infections caused by Chlamydia trachomatis or Neisseria gonorrhoeae.
Not a fit: Patients who do not have a cervicovaginal microbiota or are not at risk for sexually transmitted infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention and treatment strategies for sexually transmitted infections.
How similar studies have performed: Previous research has shown promise in understanding host-microbiota interactions in other contexts, suggesting potential for success in this novel approach.
Where this research is happening
BALTIMORE, UNITED STATES
- UNIVERSITY OF MARYLAND BALTIMORE — BALTIMORE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: RAVEL, JACQUES — UNIVERSITY OF MARYLAND BALTIMORE
- Study coordinator: RAVEL, JACQUES
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.