Understanding how the microbiome affects ear infections in children
Official title: Clinical and host microbiome features in the development of acute otitis media
Funded at Duke University · NIH-10885185 · Data updated 2026-11-12
This study is looking at how the germs in kids' bodies might affect their chances of getting ear infections, especially after they've taken antibiotics, to help find better ways to keep young children healthy and prevent these infections.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project start | July 10, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $127,359 |
| NIH project number | 5K01AI173398-02 |
| Project ID | NIH-10885185 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children aged 0 to 11 years, particularly those who have experienced recurrent ear infections or have been exposed to antibiotics early in life.
✕Less likely to help
Patients who are older than 11 years or those without a history of ear infections may not benefit from this research.
What this research studies
This research investigates the relationship between the microbiome and the development of acute otitis media (AOM), a common ear infection in children. The principal investigator, Dr. Jillian Hurst, will analyze clinical data and biological samples from children to understand how early antibiotic use may disrupt the microbiome and increase susceptibility to AOM. By examining electronic health records and samples from children from birth to age 2, the study aims to identify key factors that contribute to these infections. This work will help in developing strategies to prevent AOM and improve respiratory health in young children.
Why it matters
Potential benefit: If successful, this research could lead to better prevention strategies for ear infections in children, potentially reducing the incidence of AOM.
How similar studies have gone: Previous research has shown promising results in understanding the role of the microbiome in various infections, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Duke University
Durham, United States Active
Researchers
- Principal investigator: Hurst, Jillian Heyward — Duke University
- Study coordinator: Hurst, Jillian Heyward
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.