Understanding how the microbiome affects cervical cancer in African American women
The Microbiome and Mucosal Immunity in Cervical Cancer Disparities
This study is looking into how the bacteria in the body and the immune system might affect why African American women have higher rates of cervical cancer, even with vaccines available, and aims to find new ways to help improve their health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-11057669 on NIH RePORTER |
What this research studies
This research investigates the role of the microbiome and mucosal immunity in cervical cancer disparities specifically affecting African American women. It aims to understand why these women experience higher rates of cervical cancer and mortality despite available vaccines. The study will explore how the microbiome influences the persistence of high-risk human papillomavirus (HPV) and the progression of cervical neoplasia. By identifying key mucosal processes, the research seeks to develop new therapeutic strategies to improve health outcomes for these women.
Who could benefit from this research
Good fit: Ideal candidates for this research are African American women who are at risk for or affected by cervical cancer.
Not a fit: Patients who are not African American or those who do not have cervical cancer or HPV-related conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments and better health outcomes for African American women affected by cervical cancer.
How similar studies have performed: While the specific focus on the microbiome in cervical cancer disparities is novel, related research has shown promising results in understanding the role of the microbiome in other cancers.
Where this research is happening
Cleveland, United States
- Case Western Reserve University — Cleveland, United States (Active)
Researchers
- Principal investigator: Burgener, Adam — Case Western Reserve University
- Study coordinator: Burgener, Adam
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.