Understanding how the measles vaccine affects the immune system
Official title: Immunological and Physiological Responses to Measles Vaccine
Funded at Johns Hopkins University · NIH-11012298 · Data updated 2026-11-12
This study is looking at how the measles vaccine works in kids under 11, focusing on how it helps their immune system fight off infections and stay healthy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | January 17, 2024 |
| Project end | November 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $767,262 |
| NIH project number | 5R01AI182066-02 |
| Project ID | NIH-11012298 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation are children aged 0-11 years who are receiving or have received the measles vaccine.
✕Less likely to help
Patients who are older than 11 years or who have not received the measles vaccine may not benefit from this research.
What this research studies
This research investigates the immune and physiological responses to the measles vaccine, particularly in children under 11 years old. It aims to understand how the live attenuated measles vaccine (LAMV) interacts with the immune system, including the production of antibodies and the activation of immune cells. By studying both children and a rhesus macaque model, the research will explore the long-term effects of the vaccine on immunity and its potential role in preventing other infections. The findings could provide insights into improving vaccination strategies and understanding immune responses.
Why it matters
Potential benefit: If successful, this research could enhance the effectiveness of measles vaccination and improve overall child health by reducing mortality and morbidity associated with measles and other infections.
How similar studies have gone: Previous research has shown success in understanding immune responses to vaccines, making this approach both relevant and promising.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Pekosz, Andrew S. — Johns Hopkins University
- Study coordinator: Pekosz, Andrew S.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.