Understanding how the matrisome affects endometriosis development
The Role of the Matrisome in Endometriosis Development
This study is looking at how certain proteins in the body might affect the development of endometriosis, a painful condition many women face, by exploring how immune cells interact with uterine tissue, which could help find better ways to prevent and treat the condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Cincinnati NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project ID | NIH-10630143 on NIH RePORTER |
What this research studies
This research investigates the role of the matrisome, a collection of proteins and molecules that support cell structure, in the development of endometriosis, a painful condition affecting many women. By using a mouse model, the study examines how immune cells interact with uterine tissue to promote the attachment of endometrial cells outside the uterus. The goal is to uncover mechanisms that could lead to better prevention, diagnosis, and treatment options for endometriosis. Patients may benefit from insights that could lead to new therapies targeting the immune response in endometriosis.
Who could benefit from this research
Good fit: Ideal candidates for this research are women diagnosed with endometriosis who experience chronic pain or infertility.
Not a fit: Patients who do not have endometriosis or related autoimmune disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing and treating endometriosis, potentially alleviating pain and improving quality of life for affected women.
How similar studies have performed: Previous research has shown promising results in understanding the immune system's role in endometriosis, suggesting that this approach could yield valuable insights.
Where this research is happening
Cincinnati, United States
- University of Cincinnati — Cincinnati, United States (Active)
Researchers
- Principal investigator: Burns, Katherine Anne — University of Cincinnati
- Study coordinator: Burns, Katherine Anne
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.