Understanding how the mammalian kinetochore stays strong during cell division
Defining the mechanisms underlying the mammalian kinetochore's structural integrity under force
This study is looking at how a special part of our cells, called the kinetochore, stays strong while helping to pull apart chromosomes during cell division, which is important for understanding problems that can lead to diseases and birth defects.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-11070074 on NIH RePORTER |
What this research studies
This research investigates the mechanisms that allow the kinetochore, a crucial structure in cell division, to maintain its integrity under mechanical forces. By examining how kinetochores connect chromosomes to spindle microtubules, the study aims to uncover the physical and biochemical processes involved in chromosome segregation. The researchers will utilize advanced imaging techniques to observe these structures in live cells, providing insights into their behavior during mitosis. This knowledge could help explain errors in cell division that lead to diseases and birth defects.
Who could benefit from this research
Good fit: Ideal candidates for benefiting from this research include individuals with genetic disorders or cancers linked to cell division errors.
Not a fit: Patients with conditions unrelated to cell division or those not affected by genetic disorders may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and potential treatments for diseases caused by errors in cell division, such as certain cancers and genetic disorders.
How similar studies have performed: Previous research has shown success in understanding cellular mechanisms related to cell division, making this approach promising yet still exploring uncharted territory.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Tran, Vanna — University of California, San Francisco
- Study coordinator: Tran, Vanna
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.