Understanding how the malaria parasite Plasmodium vivax forms and develops in the liver.
Uncovering the parasite and host determinants of Plasmodium vivax hypnozoite formation and development using single cell sequencing and human liver-chimeric mice
This study is looking into how the malaria parasite can hide in the liver and cause relapses, and it's for anyone affected by malaria who wants to see better treatments and prevention methods in the future.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Seattle Children's Hospital NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-11012271 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which the malaria parasite Plasmodium vivax forms dormant stages in the liver, known as hypnozoites. Using advanced single-cell sequencing techniques and human liver-chimeric mice, the study aims to uncover the genetic and biological factors that influence hypnozoite development. By understanding these processes, researchers hope to identify new strategies for preventing malaria relapses and improving treatment options. Patients may benefit from insights that could lead to more effective anti-malarial therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living in malaria-endemic regions, particularly those infected with Plasmodium vivax.
Not a fit: Patients who are not infected with Plasmodium vivax or those living in non-endemic regions may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments that prevent malaria relapses and reduce the burden of disease in affected populations.
How similar studies have performed: While the specific approach of targeting hypnozoite formation is relatively novel, previous research has shown success in understanding other stages of the malaria life cycle.
Where this research is happening
Seattle, United States
- Seattle Children's Hospital — Seattle, United States (Active)
Researchers
- Principal investigator: Vaughan, Ashley M — Seattle Children's Hospital
- Study coordinator: Vaughan, Ashley M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.