Understanding how the LRRK2 protein is involved in diseases like Parkinson's and Alzheimer's
Molecular Mechanism of the Parkinson's Disease-associated protein LRRK2
This study is looking at a protein called LRRK2, which is connected to diseases like Parkinson's and Alzheimer's, to better understand how changes in this protein might affect these conditions and help patients in the future.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project ID | NIH-11089527 on NIH RePORTER |
What this research studies
This research investigates the LRRK2 protein, which is linked to several diseases including Parkinson's and Alzheimer's. By using advanced techniques like cryo-electron microscopy and X-ray crystallography, the study aims to uncover the molecular mechanisms and structural changes of LRRK2 caused by mutations. This could help in understanding how these mutations affect the protein's function and contribute to disease progression. Patients may benefit from insights gained about LRRK2's role in their conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Parkinson's disease or Alzheimer's disease, particularly those with known LRRK2 mutations.
Not a fit: Patients without any genetic mutations in the LRRK2 gene or those with unrelated neurodegenerative conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating diseases associated with LRRK2 mutations.
How similar studies have performed: Previous research has shown promising results in understanding the role of LRRK2 in neurodegenerative diseases, indicating that this approach has potential for success.
Where this research is happening
Indianapolis, United States
- Indiana University Indianapolis — Indianapolis, United States (Active)
Researchers
- Principal investigator: Hoang, Quyen Quoc — Indiana University Indianapolis
- Study coordinator: Hoang, Quyen Quoc
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.