Understanding how the loss of the Y chromosome affects aging
Loss of the Y Chromosome and Its Implications in Aging
This study is looking at how the loss of the Y chromosome in older men might be linked to aging and health problems, and it aims to understand how certain genetic factors play a role in this process.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Albert Einstein College of Medicine NIH-funded |
| Lab location | 1 site (Bronx, United States) |
| Project ID | NIH-11170841 on NIH RePORTER |
What this research studies
This research investigates the loss of the Y chromosome (LOY) in older men and its potential implications for aging and age-related diseases. By utilizing both computational methods and hands-on experiments, the study aims to explore the relationship between LOY and genetic factors that contribute to aging. The researchers will examine how rare genetic variants influence LOY and its connection to genome instability as people age. This comprehensive approach seeks to uncover the mechanisms linking LOY to various age-related health issues.
Who could benefit from this research
Good fit: Ideal candidates for this research are older men who may exhibit loss of the Y chromosome and are experiencing age-related health issues.
Not a fit: Patients who are younger or do not have any age-related health conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the genetic factors influencing aging and age-related diseases, potentially improving patient outcomes.
How similar studies have performed: While the investigation of LOY in aging is a relatively novel area, preliminary studies suggest that understanding chromosomal alterations could provide valuable insights into age-related diseases.
Where this research is happening
Bronx, United States
- Albert Einstein College of Medicine — Bronx, United States (Active)
Researchers
- Principal investigator: Zhang, Zhengdong — Albert Einstein College of Medicine
- Study coordinator: Zhang, Zhengdong
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.