Understanding how the loss of primary cilia affects bile duct cells and their signaling
Primary cilia loss in bile duct cells- the interplay with the autophagy machinery
This study is looking at how tiny structures in liver cells, called primary cilia, affect liver diseases like polycystic liver disease and cholangiocarcinoma, with the hope of finding new ways to help restore their function and improve treatment options for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project ID | NIH-11017063 on NIH RePORTER |
What this research studies
This research investigates the role of primary cilia, which are sensory organelles in cells, particularly in bile duct cells known as cholangiocytes. The study focuses on how defects or loss of these cilia are linked to biliary tract diseases such as polycystic liver disease and cholangiocarcinoma. By examining the mechanisms behind ciliary loss and its impact on signaling pathways, particularly the epidermal growth factor receptor (EGFR) signaling, the research aims to uncover new therapeutic strategies to restore cilia function. This could lead to innovative treatments that target the underlying causes of these diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with biliary tract diseases, such as polycystic liver disease or cholangiocarcinoma.
Not a fit: Patients without biliary tract diseases or those with conditions unrelated to ciliary dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that restore cilia function in bile duct cells, potentially improving outcomes for patients with biliary tract diseases.
How similar studies have performed: While the specific approach of targeting ciliary loss in cholangiocytes is novel, similar research has shown promise in understanding cilia's role in other diseases.
Where this research is happening
Minneapolis, United States
- University of Minnesota — Minneapolis, United States (Active)
Researchers
- Principal investigator: Gradilone, Sergio a — University of Minnesota
- Study coordinator: Gradilone, Sergio a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.