Understanding how the loss of PAX2 contributes to endometrial cancer development
Official title: Mechanisms and Consequences of PAX2 Inactivation in the Initiation of Endometrial Carcinogenesis
Funded at Ut Southwestern Medical Center · NIH-11022881 · Data updated 2026-11-12
This study is looking at how a protein called PAX2 affects the development of endometrial cancer in women, with the goal of finding out how it can help us spot the disease earlier and improve treatment options.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project start | December 2, 2024 |
| Project end | November 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $551,975 |
| NIH project number | 1R01CA295997-01 |
| Project ID | NIH-11022881 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are women aged 21 and older who are at risk for or diagnosed with endometrial cancer.
✕Less likely to help
Patients with endometrial cancer who are in advanced stages and have already undergone extensive treatment may not benefit from this research.
What this research studies
This research investigates the role of PAX2, a transcription factor, in the development of endometrial cancer, which is a significant health concern for women. The study aims to uncover the molecular mechanisms behind PAX2 inactivation and its implications for cancer initiation and progression. By analyzing tissue samples and cancer cell lines, researchers hope to identify early precursors of endometrial cancer and improve understanding of the disease's biology. This could lead to better diagnostic and therapeutic strategies for patients affected by this type of cancer.
Why it matters
Potential benefit: If successful, this research could lead to improved early detection and treatment options for endometrial cancer, potentially increasing survival rates.
How similar studies have gone: Previous research has shown promising results in understanding the molecular mechanisms of cancer through similar approaches, indicating potential for success in this area.
Where this research is happening
-
Ut Southwestern Medical Center
Dallas, United States Active
Researchers
- Principal investigator: Castrillon, Diego H — Ut Southwestern Medical Center
- Study coordinator: Castrillon, Diego H
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.