Understanding how the loss of cone cells affects vision in the retina
Synaptic and circuit mechanisms of compensation following loss of cone inputs in the mature retina
This study is looking at how losing certain light-sensing cells in the eye affects vision and behavior, with the goal of helping doctors better diagnose and track treatments for eye diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-10881549 on NIH RePORTER |
What this research studies
This research investigates how losing cone photoreceptors in the retina impacts visual circuits and behavior. It aims to establish connections between the extent of cone loss and the physiological responses of specific ganglion cells responsible for visual processing. By examining these relationships, the study seeks to improve early diagnosis and treatment monitoring for retinal diseases. The research employs a combination of behavioral assessments and physiological measurements to explore these links.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing early signs of retinal degeneration or those at risk for conditions affecting cone photoreceptors.
Not a fit: Patients with advanced retinal degeneration or those who have already lost significant vision may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to earlier diagnosis and better treatment strategies for retinal diseases, potentially preserving vision.
How similar studies have performed: Previous research has shown promising results in understanding retinal mechanisms related to cone loss, indicating that this approach has potential for significant insights.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Dunn, Felice a — University of California, San Francisco
- Study coordinator: Dunn, Felice a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.