Understanding How the KIF1A Protein Works in the Brain
Structure and Mechanism of the Kinesin-3 Motor KIF1A
This research explores how a protein called KIF1A moves things inside brain cells, which could help us understand conditions like autism.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Albert Einstein College of Medicine NIH-funded |
| Lab location | 1 site (Bronx, United States) |
| Project ID | NIH-11110335 on NIH RePORTER |
What this research studies
Our brain cells rely on a special transport system, much like tiny highways, to move important materials around. A key protein called KIF1A acts like a motor on these highways, ensuring everything gets to the right place in neurons. When KIF1A doesn't work correctly, it can lead to serious brain conditions, including those related to autism. This project uses advanced tools to look closely at KIF1A's structure and how it moves, aiming to uncover why it sometimes malfunctions. By understanding these basic mechanisms, we hope to shed light on the causes of KIF1A-related disorders.
Who could benefit from this research
Good fit: This foundational research is not directly recruiting patients but aims to benefit individuals with KIF1A-associated neurological disorders, including those with Autistic Disorder, in the future.
Not a fit: Patients whose conditions are not related to KIF1A dysfunction would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could provide fundamental insights into KIF1A-associated neurological disorders, potentially leading to new ways to help patients.
How similar studies have performed: While the general field of motor protein research is established, this specific project aims to define high-resolution structures and mechanisms of KIF1A that are currently unknown.
Where this research is happening
Bronx, United States
- Albert Einstein College of Medicine — Bronx, United States (Active)
Researchers
- Principal investigator: Gennerich, Arne — Albert Einstein College of Medicine
- Study coordinator: Gennerich, Arne
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.