Understanding how the ISG15 protein works in our immune system
Mechanism and Function of ISG15
['FUNDING_R01'] · UNIVERSITY OF TEXAS AT AUSTIN · NIH-11095961
This project explores how a protein called ISG15 helps our bodies fight off infections and regulates our immune responses.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF TEXAS AT AUSTIN (nih funded) |
| Locations | 1 site (AUSTIN, UNITED STATES) |
| Trial ID | NIH-11095961 on ClinicalTrials.gov |
What this research studies
Our bodies have a special protein called ISG15 that plays a key role in how our immune system responds to threats. This protein has several jobs, including changing other proteins, signaling to immune cells to boost defenses, and helping to control the immune system's overall activity. Sometimes, when ISG15 isn't working right, it can lead to health problems. This work aims to uncover the precise ways ISG15 carries out these important functions and how it helps us fight off specific germs like the bacteria that cause tuberculosis and the virus that causes COVID-19.
Who could benefit from this research
Good fit: This foundational research does not directly involve patient participation, but future studies based on this work might seek individuals with specific immune conditions or infections.
Not a fit: Patients not interested in the basic science of immune system proteins would not directly benefit from this particular research.
Why it matters
Potential benefit: Understanding ISG15's role could lead to new ways to treat infections and immune disorders by targeting this crucial protein.
How similar studies have performed: While the specific mechanisms of ISG15 are still being uncovered, other studies have shown the importance of ubiquitin-like proteins in immune responses.
Where this research is happening
AUSTIN, UNITED STATES
- UNIVERSITY OF TEXAS AT AUSTIN — AUSTIN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HUIBREGTSE, JON — UNIVERSITY OF TEXAS AT AUSTIN
- Study coordinator: HUIBREGTSE, JON
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.