Understanding how the intestine heals itself after injury
Official title: Consortium on Intestinal Regeneration and Fetal Reversion: from Atlas to Therapy
Funded at Cedars-Sinai Medical Center · NIH-10978104 · Data updated 2026-11-12
This study is looking at how certain cells in the intestines can heal themselves after injury, which could help people understand how their own intestines recover from things like infections or treatments.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cedars-Sinai Medical Center NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | September 1, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $2,000,000 |
| NIH project number | 1RC2DK140862-01 |
| Project ID | NIH-10978104 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals who have experienced intestinal injuries due to infections, radiation, or chemical exposure.
✕Less likely to help
Patients with stable, non-injured intestines or those with chronic conditions unrelated to intestinal injury may not benefit from this research.
What this research studies
This research investigates a unique process called fetal reversion, where intestinal cells change their gene expression to promote healing after injury. By creating a comprehensive atlas of intestinal injuries across different species, including humans, the project aims to identify key genes and pathways involved in this regenerative process. Patients may benefit from insights gained about how their intestines can repair themselves after damage from infections, radiation, or chemicals. The research will involve analyzing single-cell data to understand the dynamics of intestinal repair.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that enhance intestinal healing and regeneration in patients with various intestinal injuries.
How similar studies have gone: While the concept of fetal reversion is novel, similar regenerative approaches have shown promise in other areas of research, indicating potential for success.
Where this research is happening
-
Cedars-Sinai Medical Center
Los Angeles, United States Active
Researchers
- Principal investigator: Klein, Ophir D — Cedars-Sinai Medical Center
- Study coordinator: Klein, Ophir D
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.