Understanding How the Integrator Protein Complex Works
Elucidation of Integrator's Function
['FUNDING_R01'] · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · NIH-11091553
This project looks at how a protein complex called Integrator helps control our genes, which could affect inflammation and certain developmental conditions.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MIAMI SCHOOL OF MEDICINE (nih funded) |
| Locations | 1 site (CORAL GABLES, UNITED STATES) |
| Trial ID | NIH-11091553 on ClinicalTrials.gov |
What this research studies
The Integrator complex is a group of proteins that plays a key role in how our cells process genetic information, specifically RNA. This work aims to uncover exactly how Integrator helps turn genes on and off, including those involved in inflammation. Researchers are also exploring Integrator's connection to a protein called BRAT1, which is linked to severe developmental disorders in children. By understanding these fundamental processes, we hope to learn more about the causes of these conditions.
Who could benefit from this research
Good fit: This foundational work is relevant to patients with inflammatory conditions or those affected by specific neurodevelopmental disorders linked to genes like BRAT1.
Not a fit: Patients whose conditions are not related to gene processing, inflammation, or the specific developmental pathways being studied may not directly benefit from this particular research.
Why it matters
Potential benefit: If successful, this work could reveal new ways to understand and potentially address conditions related to inflammation and certain developmental disorders.
How similar studies have performed: This research builds upon previous discoveries about Integrator's role in gene processing and its association with other cellular pathways.
Where this research is happening
CORAL GABLES, UNITED STATES
- UNIVERSITY OF MIAMI SCHOOL OF MEDICINE — CORAL GABLES, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SHIEKHATTAR, RAMIN — UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
- Study coordinator: SHIEKHATTAR, RAMIN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.